Reduced homeobox protein MSX1 in human endometrial tissue is linked to infertility

Primary unexplained infertility is associated with reduced expression of the T-regulatory cell transcription factor Foxp3 in endometrial tissue.

A receptive endometrial environment requires adequate immunological tolerance to protect the implanting embryo from maternal immune rejection. Studies in mice implicate CD4+CD25+ T-regulatory (Treg) cells as essential mediators of immune tolerance in pregnancy. The aim of this study was to evaluate the link between Treg cells and fertility in women. Expression of Foxp3, a master regulator of Tr...

Characteristics of Human Endometrial Stem Cells in Tissue and Isolated Cultured Cells: An Immunohistochemical Aspect

Background: The aim of this study was to investigate the percentage of the stem cells population in human endometrial tissue sections and cultured cells at fourth passage. Methods: Human endometrial specimens were divided into two parts, one part for morphological studies and the other part for in vitro culture. Full thickness of human normal endometrial sections and cultured endometrial cells ...

Interpretation of Endometrial Lesions and Infertility in Mares

An endometrial factor in unexplained infertility.

OBJECTIVE To study a group of women with unexplained infertility to see whether they have a defect that is intrinsic to the endometrium. DESIGN Evaluation of the functional response of the endometrium by examining endometrial biopsy specimens using immunohistochemical methods in a group of women with unexplained infertility and in a control group of women with normal fertility. PATIENTS 27 ...

The value of endometrial biopsy in infertility.

A retrospective report of 3475 endometrial biopsies in infertile females is presented. Seventy percent were from cases with primary and 30% with secondary infertility. Biopsies were normalin 70% of cases. The remaining had proliferative endometrium (11.5%), chronic endometritis (12%), endometrial hyperplasia (3%), TB Endometritis (2.6%) and Cervical or Endometrial Polypi (0.9%). The procedure i...